Advances in Genetics 2010

Advances in Genetics

All animals use a sophisticated array of receptor proteins to sense their external and internal environments. Major advances have been made in recent years in understanding the molecular and genetic bases for sensory transduction in diverse modalities, indicating that both metabotropic and ionotropic pathways are important in sensory functions. Here, I review the historical background and recen...

Advances in osteoarthritis genetics

Osteoarthritis (OA), the most common form of arthritis, is a highly debilitating disease of the joints and can lead to severe pain and disability. There is no cure for OA. Current treatments often fail to alleviate its symptoms leading to an increased demand for joint replacement surgery. Previous epidemiological and genetic research has established that OA is a multifactorial disease with both...

Advances in Quantitative Genetics

Some issues in quantitative genetics theory, other than molecular genetic analysis and utilisation, are reviewed. These include the development of models and methods for the analysis of longitudinal data, i.e. records continued or repeated over time, such as daily milk yield within and across lactation. The problems of identifying a range of alternative models and testing their fit are discusse...

Recent advances in medical genetics.

Recent Advances in Stroke Genetics

Stroke is a complex, polygenic, and multi-factorial neurological disorder caused by a combination of environmental, vascular and genetic factors [1]. Despite new developments in the treatment and prevention, stroke accounts for the primary cause of adult disability, the second leading cause of dementia and the third leading cause of mortality in most of the developed countries [2], [3]. In the ...